Hospital-Agnostic Image Representation Learning in Digital Pathology

Whole Slide Images (WSIs) in digital pathology are used to diagnose cancer subtypes. The difference in procedures to acquire WSIs at various trial sites gives rise to variability in the histopathology images, thus making consistent diagnosis challenging. These differences may stem from variability in image acquisition through multi-vendor scanners, variable acquisition parameters, and differences in staining procedure; as well, patient demographics may bias the glass slide batches before image acquisition. These variabilities are assumed to cause a domain shift in the images of different hospitals. It is crucial to overcome this domain shift because an ideal machine-learning model must be able to work on the diverse sources of images, independent of the acquisition center. A domain generalization technique is leveraged in this study to improve the generalization capability of a Deep Neural Network (DNN), to an unseen histopathology image set (i.e., from an unseen hospital/trial site) in the presence of domain shift. According to experimental results, the conventional supervisedlearning regime generalizes poorly to data collected from different hospitals. However, the proposed hospital-agnostic learning can improve the generalization considering the lowdimensional latent space representation visualization, and classification accuracy results.