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Plasma D-dimer levels are correlated with disease severity among hypertensive patients: A comparative cross-sectional

Yanli Long1, Yi Li1, Litao Zhang2

  • 1Heart Center, Wuhan Asia Heart Hospital Affiliated Wuhan University of Science and Technology, Wuhan, China.

Medicine
|September 10, 2022
PubMed

Insights

Hypertension (HTN) is linked to increased thrombus formation. This study found higher D-dimer levels in hypertensive patients, correlating with disease severity and aiding in complication diagnosis.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Clinical Biochemistry

Background:

  • Inappropriate acute thrombus formation is implicated in hypertension-related organ damage.
  • The correlation between hypertension severity and D-dimer levels requires further characterization.

Purpose of the Study:

  • To assess plasma D-dimer levels in hypertensive patients.
  • To investigate the correlation between D-dimer levels and hypertension severity.

Main Methods:

  • A comparative cross-sectional study involving 60 hypertensive patients and 40 controls.
  • Statistical analyses included correlation coefficients, regression analysis, and parametric/nonparametric tests.

Main Results:

  • Hypertensive patients exhibited significantly higher D-dimer levels compared to controls (P < .001).
  • D-dimer levels increased significantly with hypertension severity (P < .001).
  • D-dimer demonstrated an 86.9% diagnostic power for differentiating complicated from uncomplicated hypertension at a 0.83 mg/L cutoff.

Conclusions:

  • Elevated D-dimer levels are associated with hypertension.
  • D-dimer levels correlate with hypertension severity, suggesting a role for hypercoagulability in hypertensive thromboembolic complications.

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