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Updated: Aug 29, 2025

Formation of Human Periodontal Ligament Cell Spheroids on Chitosan Films

Formation of Human Periodontal Ligament Cell Spheroids on Chitosan Films

Published on: June 19, 2019

Novel approaches for periodontal tissue engineering.

W Benton Swanson¹, Yao Yao^2,3, Yuji Mishina¹

¹Department of Biologic and Materials Science, Division of Prosthodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.

Genesis (New York, N.Y. : 2000)

|September 10, 2022

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Periodontal regeneration aims to repair tissues supporting teeth using stem cells. Research focuses on growth factors and biomaterials to improve healing predictability and long-term effectiveness.

Area of Science:

Biomaterials Science
Regenerative Medicine
Periodontology

Background:

The periodontal complex, comprising cementum, bone, and periodontal ligament (PDL), supports dentition.
Periodontitis is a common infectious disease causing irreversible damage to these supporting tissues.
Periodontal therapy seeks to repair and regenerate these tissues for preserving natural teeth and enhancing dental implant integration.

Purpose of the Study:

To review the current clinical status of periodontal regeneration.
To discuss FDA-approved growth factors and advances in preclinical research for periodontal regeneration.
To highlight novel growth factors and biomaterial matrices for improved regeneration outcomes.

Main Methods:

Review of current clinical periodontal regeneration strategies.

Keywords:

neural crest periodontology teeth tissue tissue engineering

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Last Updated: Aug 29, 2025

Formation of Human Periodontal Ligament Cell Spheroids on Chitosan Films

Formation of Human Periodontal Ligament Cell Spheroids on Chitosan Films

Published on: June 19, 2019

Experimental Approaches to Tissue Engineering

Experimental Approaches to Tissue Engineering

Published on: August 30, 2007

Two Methods for Decellularization of Plant Tissues for Tissue Engineering Applications

Two Methods for Decellularization of Plant Tissues for Tissue Engineering Applications

Published on: May 31, 2018

Analysis of FDA-approved growth factors for periodontal therapy.

Exploration of preclinical research on new growth factors and biomaterial matrices.

Main Results:

The PDL contains multipotent stem cells crucial for periodontal tissue formation.
Growth factors and biomaterial matrices are key to successful periodontal regeneration.
Advances in preclinical research are identifying new therapeutic targets.

Conclusions:

Effective periodontal regeneration relies on selecting appropriate growth factors and biomaterial matrices.
Further research into novel growth factors and biomaterials can enhance regeneration predictability and efficacy.
Understanding molecular and cellular processes is essential for comprehensive periodontal regenerative therapies.