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Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
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Central precuneus lesions are associated with impaired executive function.

Brooke E Yeager1,2, Joel Bruss2, Hugues Duffau3,4

  • 1Interdisciplinary Graduate Program in Neuroscience, University of Iowa Graduate College, Iowa City, IA, 52242, USA.

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Lesions in the central precuneus are linked to impaired executive function, specifically on the Trail-Making Test. This finding supports the central precuneus

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Brain lesionsExecutive dysfunctionLesion network mappingLesion symptom mappingTrail-making test

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience

Background:

  • The functional roles of the precuneus remain largely undefined.
  • Focal precuneus lesions are rare, hindering the establishment of brain-behavior relationships.
  • Proposed subdivisions of the precuneus suggest roles in bodily awareness, cognition, and visual processing.

Purpose of the Study:

  • To investigate the specific role of the central precuneus in executive function.
  • To test the hypothesis that the central precuneus is preferentially involved in executive function compared to other precuneus regions.
  • To correlate lesion location within the precuneus with performance on the Trail-Making Test (TMT).

Main Methods:

  • Utilized multivariate lesion symptom mapping in 35 patients with focal precuneus lesions.
  • Assessed executive function using performance on the Trail-Making Test (TMT).
  • Analyzed functional connectivity of the central precuneus region.

Main Results:

  • A statistically significant association was found between central precuneus lesions and impaired TMT performance (r=0.43, p<0.01).
  • Lesion symptom mapping identified the central precuneus as critical for TMT task performance.
  • Functional network analysis revealed connectivity of the central precuneus with areas crucial for executive function, including the dorsolateral prefrontal cortex and inferior parietal lobe.

Conclusions:

  • This study provides evidence supporting the central precuneus' role in executive function.
  • The findings align with the known connectivity patterns of the central precuneus within broader cognitive control networks.
  • The central precuneus is implicated in cognitive control and executive functions.