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Anterior segment autonomic dysfunction in ocular hypertension.

C V Clark, R Mapstone

    Documenta Ophthalmologica. Advances in Ophthalmology
    |January 1, 1986
    PubMed
    Summary
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    Autonomic nerve dysfunction, specifically parasympathetic deficits, is linked to ocular hypertension in patients with narrow irido-corneal angles. This suggests a role for autonomic dysfunction in primary glaucoma development.

    Area of Science:

    • Ophthalmology
    • Autonomic Neuroscience

    Background:

    • Ocular hypertension is a risk factor for primary open-angle glaucoma.
    • Autonomic dysfunction has been implicated in the pathogenesis of glaucoma.

    Purpose of the Study:

    • To assess autonomic nerve function in the anterior segment of the eye in patients with ocular hypertension.
    • To investigate the relationship between autonomic dysfunction and irido-corneal angle width in ocular hypertension.

    Main Methods:

    • Pupil cycle time was measured in 189 patients with ocular hypertension and 70 control subjects.
    • Patients were categorized based on irido-corneal angle width (narrow vs. wide).

    Main Results:

    • Significant parasympathetic dysfunction was observed in ocular hypertensive patients with narrow irido-corneal angles.

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  • No significant parasympathetic dysfunction was found in ocular hypertensive patients with wide irido-corneal angles.

    • Conclusions:

    • Autonomic dysfunction, particularly parasympathetic deficits, may contribute to the pathogenesis of primary glaucomas.
    • Irido-corneal angle width is a critical factor in the manifestation of autonomic dysfunction in ocular hypertension.