Related Experiment Video
Updated: Aug 29, 2025
09:01
An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
8.0K
[Parvovirus B19 infections in adults].
R Jacquot1, M Gerfaud-Valentin1, Y Mekki2
1Service de médecine interne, hospices civils de Lyon, hôpital de la Croix-Rousse, 103, Grande-Rue de la Croix-Rousse, 69317 Lyon cedex 04, France; Université de Lyon, Lyon, France.
La Revue De Medecine Interne
|September 10, 2022
Summary
Parvovirus B19 (PVB19) infection can cause various symptoms in adults, including joint pain and rarer organ-specific issues. This review explores PVB19
Area of Science:
- Virology
- Immunology
- Rheumatology
Context:
- Parvovirus B19 (PVB19) infection presents diverse clinical manifestations in adults, ranging from erythema infectiosum and polyarthralgias to rarer organ-specific syndromes.
- In immunocompromised individuals, PVB19 can lead to persistent viremia and chronic infection, manifesting as cytopenias or pure red cell aplasia in hemolytic diseases.
Purpose:
- To synthesize current clinical data on Parvovirus B19 infection in adults.
- To specifically investigate the suspected links between PVB19 infection and the development or triggering of autoimmune diseases.
Summary:
- PVB19 infection is a critical differential diagnosis for autoimmune conditions, with evidence suggesting its role in promoting autoimmune markers through mechanisms like molecular mimicry and apoptosis induction.
- While autoantibody production is partly explained by these mechanisms, a definitive causal relationship between PVB19 infection and the onset of autoimmune diseases requires further demonstration.
Impact:
- Provides a comprehensive overview of PVB19 clinical presentations in adults, aiding clinicians in diagnosis and management.
- Highlights the potential etiological role of viral infections in autoimmune disease pathogenesis, guiding future research directions.
Keywords:
Antiphospholipid syndromeLupusParvovirus B19Polyarthrite rhumatoïdeRheumatoid arthritisSAPLSystemic lupus erythematosusVascularitesVasculitisMore Related Videos
Related Concept Videos
01:25Immunodeficiency Diseases
1.2K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
1.2K
01:03Rous Sarcoma Virus (RSV) and Cancer
5.3K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.3K
00:36Viral Mutations
32.8K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
32.8K
02:33Retroviruses
12.6K
Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
12.6K
01:30Acute Pharyngitis
1.4K
Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
1.4K
01:10Retrovirus Life Cycles
46.5K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
46.5K