Related Experiment Video
Updated: Sep 8, 2026

The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport
Published on: March 6, 2015
Effect of amoxicillin on galactose transport across rat small intestine
Abstract:
The effect of amoxicillin on galactose absorption across rat small intestine was investigated by using in vivo and in vitro techniques. Amoxicillin caused a dose-related, time-dependent, and reversible inhibition in intestinal sugar transport. Intestinal galactose transport was not affected when the drug was perfused in an adjacent loop. Also, intestinal oxygen consumption was not impaired by amoxicillin. Amoxicillin decreased the apparent affinity of galactose for the carrier system, while both its maximum absorptive capacity and the phlorhizin-insensitive component of sugar absorption remained unaltered.
More Related Videos
04:40Demonstration of Membrane Transport of Histidine using Goat Intestinal Inverted Sacs: An Experiential Pedagogical Tool for Undergraduates
Published on: October 4, 2024
07:18Oral Gavage in Neonatal Mouse Pups and Functional Assessment of Gut Barrier Integrity Using Ussing Chambers
Published on: January 9, 2026
Related Concept Videos
Glucose Transporters
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Glucose Absorption Into the Small Intestine
Carbohydrate Absorption
After being swallowed, the partially digested carbohydrates mix with gastric secretions in the stomach. However, the acidic environment...
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
Methods for Studying Drug Absorption: In situ
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...