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Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
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Oral squamous cell carcinoma arising from chronic traumatic ulcers
Gerardo Gilligan1, Eduardo Piemonte2, Jerónimo Lazos2
1Oral Medicine Department, Facultad de Odontología, Universidad Nacional de Córdoba, Haya de la Torre SN, 5000, Córdoba, Argentina. ggilligan@unc.edu.ar.
Clinical Oral Investigations
|September 10, 2022
Summary
Chronic traumatic ulcers (CTUs) that do not heal may transform into oral squamous cell carcinoma (OSCC). This study highlights that non-healing CTUs (NHCTUs) can be considered potentially malignant disorders, especially on the tongue, warranting close follow-up.
Area of Science:
- Oral pathology
- Oncology
- Dental medicine
Background:
- Oral squamous cell carcinoma (OSCC) can arise from oral potentially malignant disorders (OPMDs) or de novo.
- Chronic traumatic ulcers (CTUs) are suspected but unconfirmed precursors to OSCC.
- Non-healing CTUs (NHCTUs) represent a subset of CTUs with persistent lesions.
Purpose of the Study:
- To describe the clinicopathological characteristics of non-healing CTUs (NHCTUs) that subsequently developed into oral squamous cell carcinoma (OSCC).
Main Methods:
- A retrospective cohort study was conducted from 2013-2019 at Facultad de Odontología Universidad Nacional de Córdoba.
- Patients with a provisional diagnosis of CTU were included.
- NHCTUs, defined as CTUs failing to heal after trauma removal, underwent biopsy for histological examination.
Main Results:
- Out of 107 CTUs, 32 were classified as NHCTUs.
- Two cases of NHCTU on the lateral tongue showed histological features of OSCC.
- These two individuals were non-smokers, non-drinkers, and had no other known OPMDs.
Conclusions:
- Non-healing CTUs (NHCTUs), particularly those on the tongue, carry a risk of malignant transformation into oral squamous cell carcinoma (OSCC).
- NHCTUs should be considered a potential oral potentially malignant disorder (OPMD) in certain cases.
- Regular follow-up of NHCTUs is crucial due to their low but significant malignant transformation potential.
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