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Updated: Jul 16, 2026

A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid
Published on: January 31, 2012
A robust, low swelling, and lipid-lubricated hydrogel for bionic articular cartilage substitute
Fen Xiao1, Jianxin Tang1, Xing Huang1
1Hunan Key Laboratory of Biomedical Nanometer and Device, Hunan University of Technology, Zhuzhou 412007, PR China.
Abstract:
Healthy articular cartilage can achieve high load-bearing capacity and the most effective lubricated surface. Inspired by the articular cartilage, a lipid-lubricated hydrogel with excellent mechanical strength and remarkable lubrication was designed and synthesized. The lipid-lubricated hydrogel could contribute to high strength and stiffness (compressive strength of 5.8 MPa and compressive modulus of 4.7 MPa at 50% strain), and it could recover more than 98% of original mechanical properties in a short time after loading-unloading. In addition, the friction coefficient of lipid-lubricated hydrogel is low as 0.026, 5.3 times smaller than hydrogel without adding the liposomes. Overall, the hydrogel we studied holds the potential as a load-bearing soft tissue substitute for articular cartilage.
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