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The relationship between pulse pressure with plasma PCSK9 and interleukin-6 among patients with acute ischemic stroke
Chen-Shu Chang1, Chen-Ling Kuo2, Ching-Shan Huang3
1Department of Neurology, Changhua Christian Hospital, Changhua 500, Taiwan; Department of Medical Laboratory Science and Biotechnology, Central-Taiwan University of Science of Technology, Taichung 406, Taiwan; Department of Medical Imaging and Radiological Sciences, Central-Taiwan University of Science of Technology, Taichung 406, Taiwan.
Insights
Plasma PCSK9 and interleukin-6 (IL-6) levels in acute ischemic stroke patients with dyslipidemia were studied. PCSK9 was linked to low pulse pressure, while IL-6 was associated with high pulse pressure, suggesting targeted interventions.
Area of Science:
- Cardiovascular Diseases
- Neurology
- Biochemistry
Background:
- High plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) indicates a prothrombotic state in cardiovascular diseases.
- Elevated interleukin-6 (IL-6) levels correlate with poorer outcomes in ischemic stroke patients.
- The study investigates the roles of PCSK9 and IL-6 in acute ischemic stroke patients with dyslipidemia.
Purpose of the Study:
- To examine the association between plasma PCSK9 and IL-6 levels and acute ischemic stroke.
- To explore the relationship between these markers and pulse pressure subgroups in stroke patients.
- To understand the implications for dyslipidemia management and secondary stroke prevention.
Main Methods:
- 123 patients with first-ever acute ischemic stroke were categorized into normotensive and high blood pressure groups, with further division into low and high pulse pressure subgroups.
- Clinical characteristics, inflammatory markers (IL-6), and metabolic parameters (PCSK9) were recorded.
- Statistical analyses were performed to identify correlations and associations.
Main Results:
- Positive correlations were observed between pulse pressure and carotid stenosis/plaque numbers, and between NIH Stroke Scale scores and carotid stenosis severity/resistance index.
- Plasma cholesterol showed a significant association with PCSK9 in the low pulse pressure subgroup (P=0.044).
- Interleukin-6 (IL-6) was significantly associated with the high pulse pressure subgroup (P=0.042).
Conclusions:
- Plasma PCSK9 levels are associated with the low pulse pressure subgroup in acute ischemic stroke.
- Interleukin-6 (IL-6) levels are associated with the high pulse pressure subgroup.
- Effective dyslipidemia control is crucial for stroke patients, especially those with high pulse pressure, necessitating further research into PCSK9 and IL-6 roles for early treatment and prevention.
Background And Purpose:
A high plasma concentration of proprotein convertase subtilisin/kexin type 9 is characteristic of a prothrombotic state in cardiovascular diseases. Elevated inflammatory markers, such as interleukin-6, are associated with worse outcomes after ischemic stroke. We aimed to study the role of plasma PCSK9 and IL-6 in acute ischemic stroke with dyslipidemia.
Methods:
We divided 123 enrolled patients with first-ever acute ischemic stroke into normotensive and high blood pressure groups and further into high and low pulse pressure subgroups. Clinical characteristics and inflammatory and metabolic parameters, including plasma PCSK9 and IL-6, were recorded.
Results:
After the analysis of the normotensive and BP groups, there were positive correlations between PP and carotid stenosis (P = 0.031) and plaque numbers (P = 0.013) and between National Institute of Health Stroke Scale scores (P = 0.019) and carotid stenosis severity (P = 0.021) and resistance index (P = 0.04). There was a significant association between plasma cholesterol and PCSK9 (P = 0.044) in the low PP subgroup and IL-6 (P = 0.042) in the high PP subgroup.
Conclusions:
Our findings indicated that plasma PCSK9 levels were associated with the low PP subgroup, while IL-6 was associated with the high PP subgroup. Dyslipidemia control is also necessary for those who had a stroke and who have high PP. Further investigation to assess the role of PCSK9 and IL-6 in patients with stroke is required for early treatment and secondary prevention.
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