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Protein scaffolds in human clinics.

Olivia Cano-Garrido1, Naroa Serna2, Ugutz Unzueta3

  • 1Institut de Biotecnologia i de Biomedicina, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès (Barcelona), Spain.

Biotechnology Advances
|September 11, 2022
PubMed
Summary

Human proteins and humanized protein variants offer biocompatible, biodegradable, and tunable materials for drug delivery and regenerative medicine. Engineering these proteins into self-assembling scaffolds overcomes immunotoxicity concerns for clinical applications.

Keywords:
Protein materialsdrug deliveryhuman proteinhumanizationnanomedicineregenerative medicine, self-assembling

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Nanotechnology

Background:

  • Biocompatible materials are crucial for drug delivery and regenerative medicine, with polypeptides offering advantages like biodegradability and tunable properties.
  • Non-human proteins can cause immunotoxicities, limiting their clinical use.
  • Developing non-immunogenic protein materials necessitates using human or humanized proteins.

Purpose of the Study:

  • To review human and humanized proteins engineered for scaffolding functions.
  • To explore their self-assembly into oligomers, polymers, and networks.
  • To highlight proteins in clinical development for advanced applications.

Main Methods:

  • Review of literature on engineered human and humanized proteins for biomaterial applications.
  • Analysis of protein self-assembly mechanisms into various material forms.
  • Examination of clinical development status and functional adaptations of these protein materials.

Main Results:

  • An expanding catalogue of human/humanized proteins designed for scaffolding functions exists.
  • These proteins can be engineered into self-assembling oligomers, polymers, and networks.
  • Several such protein materials are under clinical development, offering refined functions beyond mechanical support.

Conclusions:

  • Human and humanized proteins are promising non-immunogenic building blocks for advanced biomaterials.
  • Engineered protein self-assembly enables versatile material architectures for diverse clinical needs.
  • Ongoing clinical development signifies the therapeutic potential of these advanced protein-based materials.