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Updated: Aug 29, 2025

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
Published on: March 24, 2023
[A Case of Occupational Contact Dermatitis Caused by Rubber Gloves]
Hikaru Kawahara-Nanamori1, Yu Sawada1
1Department of Dermatology, School of Medicine, University of Occupational and Environmental Health, Japan.
Abstract:
A 42-year-old man working at a steel mill recognized itching and erythema on the dorsal surfaces of his hands for 2 weeks prior to his first visit to our department. Lichenized erythematous plaques were observed on the dorsal surfaces of his fingers and hands. A patch testing of the rubber part of the gloves showed a positive reaction. We also conducted a patch testing of metals to exclude a possibility of contact dermatitis mediated by metals as occupational materials. The patch testing of metals showed a positive reaction to zinc, which is not an occupational material in his steel mill, but his rubber gloves contained zinc in the rubber accelerators, which might have been the trigger that caused his allergic contact dermatitis. Contact dermatitis is the most common occupational skin disease, and various materials are the causative agents. Allergic reactions to rubber (latex) are classified into type I allergy and type IV allergy. Type IV allergic reaction is observed in rubber accelerators such as thiuram; however, our case showed that zinc allergy could be a possible causative agent in patients with contact dermatitis due to rubber gloves.
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