Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

3.0K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
3.0K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

664
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
664
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

2.7K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.7K
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

232
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
232
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

11.5K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.5K
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

341
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
341

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

LCR-modules: a collection of workflows for cancer genome analysis.

Bioinformatics (Oxford, England)·2026
Same author

A Phase 2 Trial of Frexalimab, a CD40L Antagonist, in Adolescents and Adults With Recent-Onset Type 1 Diabetes (FABULINUS): Rationale and Study Design.

Diabetes, obesity & metabolism·2026
Same author

HNRNPU mutations redirect cell cycle control to E2F in MYC-driven lymphomas.

Blood advances·2026
Same author

Development of High-Affinity Ligands for Human UBR2.

Journal of medicinal chemistry·2026
Same author

Low-Dose Antithymocyte Globulin in Type 1 Diabetes: Real-World Exploratory Observation of C-Peptide by Modified Quantitative Response (mQR).

Diabetes care·2026
Same author

Metabolic Implications of PCOS.

Current pediatrics reports·2026
Same journal

Mapping Lifestyle Factors in Blood Glucose Variability in Adolescents With Type 1 Diabetes Mellitus: A Pilot Study.

Pediatric diabetes·2026
Same journal

Achieving Glycemic Targets in and out-of-School: Real-World Data From 1341 Italian Children Using the MiniMed 780G System During Auto Mode.

Pediatric diabetes·2026
Same journal

Sex-Specific BMI Trajectories in Young People With Type 1 Diabetes: A 20-Year Retrospective Regional Audit.

Pediatric diabetes·2026
Same journal

Treatment of Youth-Onset Type 2 Diabetes: Focus on SGLT-2 Inhibitor Use.

Pediatric diabetes·2026
Same journal

Pediatric Hepatocyte Nuclear Factor 1B (<i>HNF1B</i>) Disease: Diabetes and Endocrine Manifestations.

Pediatric diabetes·2026
Same journal

Epidemiological Trends and Seasonal Patterns in Childhood Type 1 Diabetes: Insights From 2001 to 2024 in Lithuania.

Pediatric diabetes·2026
See all related articles

Related Experiment Video

Updated: Aug 29, 2025

Electrochemiluminescence Assays for Human Islet Autoantibodies
09:15

Electrochemiluminescence Assays for Human Islet Autoantibodies

Published on: March 23, 2018

15.6K

Type 1 diabetes knowledge assessment: The KAT-1 validation study.

Anastasia Albanese-O'Neill1,2, Jann MacInnes3, Michael J Haller1

  • 1College of Medicine, University of Florida, Gainesville, Florida, USA.

Pediatric Diabetes
|September 11, 2022
PubMed
Summary
This summary is machine-generated.

The newly developed KAT-1 tool accurately assesses pediatric type 1 diabetes knowledge in children and parents. This valid instrument helps personalize diabetes education by identifying specific knowledge gaps.

Keywords:
Electronic health recordPatient educationPediatricsSelf-managementType 1 diabetes mellitus

More Related Videos

Isolation of Human Islets from Partially Pancreatectomized Patients
11:10

Isolation of Human Islets from Partially Pancreatectomized Patients

Published on: July 30, 2011

16.4K
A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

2.9K

Related Experiment Videos

Last Updated: Aug 29, 2025

Electrochemiluminescence Assays for Human Islet Autoantibodies
09:15

Electrochemiluminescence Assays for Human Islet Autoantibodies

Published on: March 23, 2018

15.6K
Isolation of Human Islets from Partially Pancreatectomized Patients
11:10

Isolation of Human Islets from Partially Pancreatectomized Patients

Published on: July 30, 2011

16.4K
A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

2.9K

Area of Science:

  • Pediatric Endocrinology
  • Diabetes Education
  • Health Assessment Tools

Background:

  • Type 1 diabetes (T1D) management requires comprehensive knowledge for patients and caregivers.
  • Existing knowledge assessments may not be tailored for pediatric populations or integrated into clinical workflows.
  • Objective assessment of T1D knowledge is crucial for effective patient education and improved health outcomes.

Purpose of the Study:

  • To evaluate the reliability and validity of the Knowledge Assessment Tool-1 (KAT-1), a novel instrument for assessing T1D knowledge.
  • To determine if KAT-1 scores correlate with established measures (DKT2) and clinical indicators (HbA1c).
  • To assess the internal consistency and usability of KAT-1 for children, adolescents, young adults, and their parents/guardians.

Main Methods:

  • Development of KAT-1 by a multidisciplinary team, including a pilot study for refinement.
  • Validation study involving 200 participants (100 pediatric T1D patients, 100 parents/guardians).
  • Correlational analysis of KAT-1 scores with the Revised Diabetes Knowledge Test (DKT2) and HbA1c levels; internal consistency assessed using Cronbach's alpha.

Main Results:

  • KAT-1 scores showed significant positive correlation with DKT2 scores (r=0.674, p<0.001) and negative correlation with HbA1c (r=-0.3, p<0.001).
  • High internal consistency for the total KAT-1 score (Cronbach's α=0.938) and 9 out of 11 subscales.
  • Subscales demonstrated strong inter-correlations and rapid completion times (<5 minutes).

Conclusions:

  • KAT-1 is a reliable and valid instrument for assessing type 1 diabetes knowledge in pediatric patients and their families.
  • The tool's modular subscales allow for objective assessment of specific knowledge areas, facilitating individualized diabetes education.
  • KAT-1 is integrated into electronic health records and freely available online.