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COVID-19 Vaccination Breakthrough Infections in a Real-World Setting: Using Community Reporters to Evaluate Vaccine
Matthew W Reynolds1, Yiqiong Xie1, Kendall B Knuth1
1Real World Solutions, IQVIA, Cambridge, MA, USA.
Infection and Drug Resistance
|September 12, 2022
Summary
Community volunteers found that COVID-19 vaccines significantly reduce infection severity. Most fully vaccinated individuals experienced mild or no symptoms, demonstrating vaccine effectiveness in preventing severe illness.
Area of Science:
- Public Health
- Immunology
- Pharmacovigilance
Background:
- The COVID-19 pandemic necessitates robust pharmacovigilance methods.
- Understanding vaccine effectiveness and breakthrough infection characteristics is crucial.
Purpose of the Study:
- To systematically gather information on COVID-19 vaccine effectiveness.
- To characterize the nature and severity of breakthrough infections using community volunteers.
Main Methods:
- An online registry collected data from 11,826 community volunteers between December 2020 and September 2021.
- Data included COVID-19 test results, vaccination status (Pfizer, Moderna, J&J), and symptoms.
- Infections were categorized by vaccination status: fully vaccinated, partially vaccinated, or unvaccinated.
Main Results:
- Among vaccinated participants, 1.0% of fully vaccinated and 2.3% of partially vaccinated individuals reported infections.
- Fully vaccinated individuals with breakthrough infections experienced predominantly asymptomatic or mild symptoms (over 97%).
- Only 1.4% of fully vaccinated participants reported moderate-to-severe symptoms, compared to 7.8% of unvaccinated individuals.
Conclusions:
- Person-generated health data (patient-reported outcomes) effectively quantifies breakthrough infections and their severity.
- This approach is valuable for comparing the effectiveness of different COVID-19 vaccines.
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