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Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
Deterioration of bladder compliance after botulinum toxin A injection and discontinuation of medication for
Naoki Wada1, Mayumi Ishikawa1, Masaya Nagabuchi1
1Department of Renal and Urologic Surgery Asahikawa Medical University Asahikawa Japan.
Introduction:
We report a case of deterioration of bladder compliance after botulinum toxin type A injection and discontinuation of medication for overactive bladder.
Case Presentation:
A female patient with overactive bladder in her sixties had been visiting our outpatient clinic regularly for 4 years. She had received posterolateral spondylus fusion twice, which resulted in a compression fracture. She had been receiving a combination therapy of anticholinergics and β3-adrenoceptor agonist for the management of overactive bladder. She received botulinum toxin type A injection for refractory overactive bladder and discontinued medical treatment for overactive bladder. Three months after botulinum toxin type A injection, cystometry revealed the deterioration of bladder compliance. Renal dysfunction, hydronephrosis, and vesicoureteral reflux were shown. Renal function and hydronephrosis were improved after restarting anticholinergics and β3-adrenoceptor agonist therapy and inserting a temporary transurethral catheter.
Conclusion:
Deterioration of bladder compliance may occur after botulinum toxin type A injection and discontinuation of overactive bladder medication in some patients with underlying neurological disease.
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