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Serotoninergic neurons: long-lasting activation by a possible antidepressant dihydroergosine
European Journal of Pharmacology
|May 7, 1987
Abstract:
The duration of the stimulating effect of one single i.p. injection of a possible antidepressant dihydroergosine (50 mg/kg) on the 5-HT syndrome was studied in rats. Dihydroergosine produced a very pronounced stimulation of the 5-HT syndrome which was still present after 1-144 h (6 days). The results suggest that dihydroergosine produces a long-lasting stimulation of serotoninergic neurons.