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The interaction between cellular senescence and chronic kidney disease as a therapeutic opportunity

Jing-Li Zhao1, Xiao-Hui Qiao2, Jian-Hua Mao1

  • 1Department of Nephrology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.

Frontiers in Pharmacology
|September 12, 2022
PubMed

Insights

Cellular senescence, a state of irreversible cell cycle arrest, is closely linked to chronic kidney disease (CKD). Targeting senescent cells offers a promising therapeutic strategy for CKD intervention.

Area of Science:

  • Nephrology
  • Cell Biology
  • Gerontology

Background:

  • Chronic kidney disease (CKD) presents a global health challenge with limited effective treatments.
  • Cellular senescence, marked by cell cycle arrest and specific secretory phenotypes, is implicated in aging and disease.
  • The relationship between renal senescence and CKD is complex, with unclear causal links.

Purpose of the Study:

  • To review the commonalities between renal senescence and CKD.
  • To explore the interactive mechanisms linking renal senescence and CKD.
  • To discuss senotherapy strategies for CKD intervention.

Main Methods:

  • Literature review and synthesis of existing research on renal senescence and CKD.
  • Analysis of cellular signaling pathways involved in the senescence-CKD interaction.
  • Examination of current and potential senotherapeutic approaches.

Main Results:

  • Renal senescence and CKD share etiological, mechanistic, pathological, phenotypic, and outcome similarities.
  • Complex interactions exist between renal senescence and CKD, mediated by various cellular signaling pathways.
  • Senotherapy emerges as a potential therapeutic avenue for CKD.

Conclusions:

  • Understanding the interplay between renal senescence and CKD is crucial for developing novel therapeutic strategies.
  • Targeting cellular senescence holds promise for future CKD interventions.
  • Further research is needed to elucidate open questions regarding senotherapy in CKD.
Keywords:
cellular senescencechronic kidney diseaseinteractionmechanismtherapy

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