Related Experiment Video
Updated: Aug 29, 2025
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
39.0K
Apremilast in Paediatric Dermatoses - A Comprehensive Review
Nibedita Patro1, Maitreyee Panda2, Mrityunjay Dash3
1Department of Skin and VD, Hi-Tech Medical College and Hospital, Utkal University, Bhubaneswar, Odisha, India.
Indian Journal of Dermatology
|September 12, 2022
Summary
Apremilast is an effective treatment for pediatric dermatological conditions like psoriasis. It offers a favorable safety profile compared to traditional immunosuppressants, making it a valuable option for children.
Area of Science:
- Dermatology
- Pediatrics
- Pharmacology
Background:
- Apremilast is gaining recognition for treating various skin conditions, notably psoriasis.
- Its efficacy is comparable to immunosuppressive drugs, but with a better side effect profile.
- This positions apremilast as a suitable alternative for managing diverse dermatoses.
Purpose of the Study:
- To review existing literature on the use of apremilast in pediatric patients.
- To evaluate the effectiveness and safety of apremilast for dermatological conditions in children.
Main Methods:
- Literature search of studies involving apremilast in pediatric populations.
- Analysis of reported outcomes, including efficacy and adverse events.
Main Results:
- Apremilast demonstrates comparable effectiveness to immunosuppressive therapies in pediatric dermatoses.
- The drug exhibits a favorable side effect profile in children.
- Evidence suggests apremilast is a prudent therapeutic choice for pediatric skin conditions.
Conclusions:
- Apremilast is a viable and safe treatment option for various dermatological conditions in children.
- Its efficacy and tolerability support its use as an alternative to traditional immunosuppressants.
Related Concept Videos
01:20Asthma: Pathogenesis and Management
538
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
538
01:30Asthma-IV: Diagnostic and Management
2.6K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.6K
01:19Antiasthma Drugs: Leukotriene Modifiers
421
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
421
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
412
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
412
01:26Asthma-II: Pathophysiology and Classification
2.8K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.8K
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
366
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
366