Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spherical radiomics for radiogenomic assessment of glioblastoma heterogeneity.

Neuro-oncology advances·2026
Same author

Inverse Design of Anthraquinone-Mimicking COFs via Electronic Fingerprints for Sacrificial-Agent-Free Photocatalytic H<sub>2</sub>O<sub>2</sub> Production under Visible Light.

Journal of the American Chemical Society·2026
Same author

Integrating multi-omics and machine learning to explore the role of amino acid metabolism in intervertebral disk degeneration.

Frontiers in neurology·2026
Same author

Anisotropic electronic correlations in the spin density wave state of La<sub>3</sub>Ni<sub>2</sub>O<sub>7</sub>.

Nature communications·2026
Same author

Optimization of Extraction Process for Flavonoids from <i>Sonchus oleraceus</i> L. and Evaluation of Anti-Inflammatory Activity of Luteoloside.

Molecules (Basel, Switzerland)·2026
Same author

Biomechanical investigation of spinal cord stress changes following ACAF for different subtypes of cervical OPLL.

Scientific reports·2026

Related Experiment Video

Updated: Aug 29, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.5K

Fixed Beamline Optimization for Intensity Modulated Carbon-Ion Therapy.

Pavitra Ramesh1, Hengjie Liu1, Wenbo Gu2

  • 1Physics and Biology in Medicine interdepartmental program, University of California Los Angeles, Los Angeles, CA 90025 USA.

IEEE Transactions on Radiation and Plasma Medical Sciences
|September 12, 2022
PubMed
Summary

Optimizing treatment couch angle in fixed beam heavy ion therapy can overcome limitations of rotational gantries. This approach improves patient treatment by achieving comparable results to ideal scenarios.

Keywords:
beam orientationcarbon iongantryheavy ionoptimization

More Related Videos

Sample Preparation and Experimental Design for In Situ Multi-Beam Transmission Electron Microscopy Irradiation Experiments
08:31

Sample Preparation and Experimental Design for In Situ Multi-Beam Transmission Electron Microscopy Irradiation Experiments

Published on: June 27, 2022

1.8K
X-ray Beam Induced Current Measurements for Multi-Modal X-ray Microscopy of Solar Cells
10:16

X-ray Beam Induced Current Measurements for Multi-Modal X-ray Microscopy of Solar Cells

Published on: August 20, 2019

13.9K

Related Experiment Videos

Last Updated: Aug 29, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.5K
Sample Preparation and Experimental Design for In Situ Multi-Beam Transmission Electron Microscopy Irradiation Experiments
08:31

Sample Preparation and Experimental Design for In Situ Multi-Beam Transmission Electron Microscopy Irradiation Experiments

Published on: June 27, 2022

1.8K
X-ray Beam Induced Current Measurements for Multi-Modal X-ray Microscopy of Solar Cells
10:16

X-ray Beam Induced Current Measurements for Multi-Modal X-ray Microscopy of Solar Cells

Published on: August 20, 2019

13.9K

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Biomedical Engineering

Background:

  • Rotational gantries for heavy ion therapy are costly and technically challenging.
  • Fixed beamlines are a common compromise, but may limit treatment precision.
  • Optimizing couch angle offers a potential solution to enhance fixed beamline efficacy.

Purpose of the Study:

  • To investigate the efficacy of optimized treatment couch angle in mitigating dosimetric limitations of fixed beam heavy ion therapy.
  • To compare treatment plans generated with fixed beamlines (with and without couch rotation) against ideal gantry and couch rotation scenarios.

Main Methods:

  • Formulated an integrated beam orientation and scanning spot optimization problem using a quadratic cost function with group sparsity regularization.
  • Employed the fast iterative shrinkage-thresholding algorithm (FISTA) for efficient problem solving.
  • Developed and compared intensity modulated carbon-ion therapy (IMCT) plans for ten pancreas cases under fixed beamline (FB), fixed beamline with couch rotation (FBCR), and gantry/couch rotation (GCR) conditions.

Main Results:

  • Fixed beamline with couch rotation (FBCR) plans demonstrated comparable planning target volume (PTV) coverage to the ideal gantry/couch rotation (GCR) scenario.
  • Organ at Risk (OAR) doses in FBCR plans were also found to be comparable to GCR plans across all ten pancreas cases.
  • The study successfully validated the effectiveness of the proposed optimization method.

Conclusions:

  • Optimized couch rotation significantly mitigates the dosimetric limitations associated with fixed beam heavy ion radiotherapy.
  • This approach offers a practical and cost-effective alternative to expensive rotational gantries.
  • Integrated beam orientation optimization of couch rotation is a promising strategy for enhancing heavy ion therapy adoption.