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Serum SCUBE-1 Levels and Return of Spontaneous Circulation Following Cardiopulmonary Resuscitation in Adult Patients

Cahit Yılmaz1, Bedia Gülen2, Ertan Sönmez3

  • 1Department of Emergency Medicine, University of Health Sciences Umraniye Training and Research Hospital, Istanbul, Turkey.

Avicenna Journal of Medicine
|September 12, 2022
PubMed

Insights

Serum soluble protein SCUBE-1 may predict return of spontaneous circulation (ROSC) after cardiopulmonary resuscitation (CPR). Higher SCUBE-1 levels in patients achieving ROSC suggest its potential as a prognostic biomarker in critical care.

Area of Science:

  • Biochemistry
  • Cardiology
  • Critical Care Medicine

Background:

  • SCUBE-1 is a soluble protein investigated as a biomarker for myocardial infarction, stroke, mesenteric ischemia, and gastric cancer.
  • Its role in predicting outcomes following cardiopulmonary resuscitation (CPR) remains largely unexplored.

Purpose of the Study:

  • To investigate the association between serum SCUBE-1 levels and the achievement of return of spontaneous circulation (ROSC) in patients undergoing CPR.
  • To evaluate SCUBE-1 as a potential prognostic biomarker for ROSC.

Main Methods:

  • A case-control study involving 50 adult patients (25 ROSC, 25 non-survivors) who received CPR.
  • Serum SCUBE-1 levels and routine biochemical parameters were measured at admission.
  • Statistical analysis compared SCUBE-1 levels between the ROSC and non-survivor groups.

Main Results:

  • No significant differences in age or gender distribution were observed between the groups.
  • Serum SCUBE-1 levels were significantly higher in patients who achieved ROSC compared to non-survivors (p < 0.05).
  • At a cut-off of 9 ng/mL, SCUBE-1 demonstrated 100% sensitivity and 100% negative predictive value for predicting ROSC.

Conclusions:

  • Elevated serum SCUBE-1 levels are significantly associated with successful ROSC in patients who received CPR.
  • SCUBE-1 shows promise as a sensitive biomarker for predicting ROSC, warranting further investigation in larger cohorts.

Keywords:
SCUBE−1 proteincardiopulmonary resuscitationpeptides

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