Involvement of the central nervous system in malignant lymphomas of mice

19% of the male and 49% of the female AKR mice with spontaneously developed lymphomas show an involvement of the central nervous system (CNS) in the form of a tumor cell infiltration of the leptomeninx. A significantly higher rate of lymphomas was achieved by syngeneic transplantation of lymphoma cells (intraperitoneal inoculation) in the CNS with 87% in both sexes. Morphologically, there were no differences between the leptomeningeal infiltrations in spontaneously developed and transplanted lymphomas. Spontaneous and induced lymphomas of the AKR mouse may be suitable as a simple model for investigations on CNS lymphomas in experimental oncology.