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Updated: Aug 29, 2025

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
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Emerging ROS-Modulating Technologies for Augmentation of the Wound Healing Process.

Suryanarayana Polaka1, Pratik Katare1, Bhakti Pawar1

  • 1National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A), An Institute of National Importance, Government of India, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Palaj, Opposite Air Force Station, Gandhinagar 382355, Gujarat, India.

ACS Omega
|September 12, 2022
PubMed
Summary

Reactive oxygen species (ROS) play a dual role in wound healing. While low levels aid healing, excessive ROS prolong inflammation, hindering recovery. Antioxidant therapies targeting ROS show promise for chronic wound treatment.

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Area of Science:

  • Biomedical Science
  • Wound Healing Research
  • Oxidative Stress Biology

Background:

  • Reactive oxygen species (ROS) are crucial mediators in biological processes, exhibiting a dual role in wound healing.
  • Slightly elevated ROS levels can inhibit microbial infection, promoting early wound healing stages.
  • Conversely, excessive ROS accumulation at wound sites exacerbates inflammation, impeding the healing cascade and leading to chronic wounds.

Purpose of the Study:

  • To comprehensively review the intricate relationship between ROS and the critical phases of wound healing.
  • To elucidate the molecular and biomolecular mechanisms underlying ROS-mediated effects on cellular homeostasis and inflammation during wound repair.
  • To explore the potential of exogenous antioxidant therapeutics in manipulating ROS levels for enhanced chronic wound healing.

Main Methods:

  • Literature review synthesizing current research on ROS in wound healing.
  • Analysis of molecular pathways affected by ROS during different healing phases.
  • Evaluation of antioxidant therapeutic strategies targeting ROS scavenging for wound management.

Main Results:

  • ROS exhibit a biphasic effect on wound healing, beneficial at low concentrations and detrimental at high concentrations.
  • Excessive ROS disrupt cellular homeostasis and prolong the inflammatory phase, delaying wound closure.
  • Understanding ROS modulation is key to developing effective antioxidant therapies for chronic wounds.

Conclusions:

  • Targeting ROS represents a promising therapeutic strategy for improving chronic wound healing outcomes.
  • Antioxidant therapies that scavenge excess ROS can restore cellular balance and promote timely wound resolution.
  • Further research into ROS-mediated mechanisms will refine the application of antioxidant therapeutics in regenerative medicine.