Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

155
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
155
Depression: Overview01:18

Depression: Overview

326
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
326
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

202
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
202
Dementia01:30

Dementia

159
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
159
Long-term Depression01:05

Long-term Depression

31.3K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
31.3K
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

640
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
640

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Physiological and Molecular Links Between Physical Activity and Brain Health: A Review.

Neuroscience insights·2023
Same author

Preserving and enhancing mitochondrial function after stroke to protect and repair the neurovascular unit: novel opportunities for nanoparticle-based drug delivery.

Frontiers in cellular neuroscience·2023
Same author

Gene therapy strategies for glaucoma from IOP reduction to retinal neuroprotection: Progress towards non-viral systems.

Advanced drug delivery reviews·2023
Same author

Microparticles generated during chronic cerebral ischemia deliver proapoptotic signals to cultured endothelial cells.

Biochemical and biophysical research communications·2014
Same author

The effects of high- and low-risk environments on cognitive function in rats following 2-vessel occlusion of the carotid arteries: a behavioral study.

Behavioural brain research·2013
Same author

A concerted appeal for international cooperation in preclinical stroke research.

Stroke·2013

Related Experiment Video

Updated: Aug 29, 2025

A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

21.1K

Perspectives on the complex links between depression and dementia.

Antoine Hakim1,2

  • 1Brain and Mind Research Institute, University of Ottawa, Ottawa, ON, Canada.

Frontiers in Aging Neuroscience
|September 12, 2022
PubMed
Summary

Depression significantly increases dementia risk by activating inflammation and reducing cerebral blood flow. Treating depression may help prevent cognitive decline, but only with specific anti-inflammatory antidepressants.

Keywords:
cerebral small vessel diseasedementiadepressioninflammationrisk factorstreatment

More Related Videos

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

768
An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

22.7K

Related Experiment Videos

Last Updated: Aug 29, 2025

A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

21.1K
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

768
An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

22.7K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Gerontology

Background:

  • Depression is a prevalent mental health issue with significant societal and economic costs.
  • Growing evidence suggests a link between depression and increased risk of cognitive decline, including Alzheimer's disease.

Purpose of the Study:

  • To review the physiological mechanisms linking depression to dementia.
  • To explore how depression acts as a risk factor for cognitive impairment.

Main Methods:

  • Literature review of studies examining the physiological pathways between depression and dementia.
  • Analysis of pro-inflammatory mediators and their role in cerebral small vessel disease.

Main Results:

  • Depression and its precursors activate pro-inflammatory pathways, contributing to cerebral small vessel disease and reduced cerebral blood flow.
  • These physiological changes mirror those associated with other known dementia risk factors.
  • The impact of depression treatment on cognitive decline is variable, suggesting a need for targeted therapies.

Conclusions:

  • Depression is a significant, treatable risk factor for dementia, mediated by inflammatory processes.
  • Future research should focus on antidepressants that specifically target inflammation to mitigate cognitive decline.