Recent developments in one-pot stepwise synthesis (OPSS) of small molecules

Area of Science:

• Organic Chemistry
• Synthetic Chemistry

Background:

• One-pot synthesis is advantageous due to efficiency and reduced waste.
• One-pot stepwise synthesis (OPSS) offers greater flexibility than cascade or multicomponent reactions.
• OPSS allows for variable reaction conditions across multiple steps.

Purpose of the Study:

• To highlight recent advancements in one-pot stepwise synthesis.
• To showcase OPSS applications in synthesizing diverse chemical structures.
• To provide a perspective on the utility of OPSS in modern organic synthesis.

Main Methods:

• Review of selected literature examples demonstrating OPSS.
• Focus on reactions including cyclization, cycloaddition, rearrangement, and catalysis.
• Application of OPSS for synthesizing heterocyclic scaffolds, asymmetric molecules, natural products, and bioactive compounds.

Main Results:

• Demonstrated the versatility of OPSS across various reaction types.
• Highlighted the successful synthesis of complex molecular targets using OPSS.
• Showcased OPSS as a practical and adaptable synthetic strategy.

Conclusions:

• One-pot stepwise synthesis is a powerful and flexible strategy in organic chemistry.
• OPSS enables efficient and practical synthesis of diverse and valuable compounds.
• Recent developments underscore the growing importance of OPSS in synthesizing complex molecules.