Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Metastasis02:30

Metastasis

5.7K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.7K
The Tumor Microenvironment02:17

The Tumor Microenvironment

6.7K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrated Genomic and Epigenomic Analysis Reveals Epigenetic Plasticity in Disease Progression and Multidrug Resistance in Multiple Myeloma.

Cancer research·2026
Same author

Cancer Evolvability Determines Therapy Outcomes.

bioRxiv : the preprint server for biology·2026
Same author

Modeling VEGF and GLUT1 Expression as Coadapted Foraging Strategies in Cancer.

bioRxiv : the preprint server for biology·2026
Same author

Clinical AI in Radiology: Foundations, Trends, Applications, and Emerging Directions.

Cancers·2026
Same author

Migrastatic therapy as a potential game-changer in adaptive cancer treatment.

Scientific reports·2026
Same author

Distinct Tumor-Immune Ecologies in Patients with Lung Cancer Predict Progression and Define a Clinical Biomarker of Therapy Response.

Cancer research·2025

Related Experiment Video

Updated: Aug 29, 2025

Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior
09:44

Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior

Published on: June 13, 2016

8.5K

Interdisciplinary approaches to metastasis.

Stephen W Smye1, Robert A Gatenby2

  • 1School of Medicine, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK.

Iscience
|September 12, 2022
PubMed
Summary

Interdisciplinary research, combining physics and cancer biology, is advancing the understanding of metastasis. This collaborative approach highlights novel strategies for tackling this major challenge in cancer research.

More Related Videos

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

2.5K
Pathological Analysis of Lung Metastasis Following Lateral Tail-Vein Injection of Tumor Cells
08:54

Pathological Analysis of Lung Metastasis Following Lateral Tail-Vein Injection of Tumor Cells

Published on: May 20, 2020

9.2K

Related Experiment Videos

Last Updated: Aug 29, 2025

Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior
09:44

Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior

Published on: June 13, 2016

8.5K
A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

2.5K
Pathological Analysis of Lung Metastasis Following Lateral Tail-Vein Injection of Tumor Cells
08:54

Pathological Analysis of Lung Metastasis Following Lateral Tail-Vein Injection of Tumor Cells

Published on: May 20, 2020

9.2K

Area of Science:

  • Cancer Biology
  • Physics
  • Interdisciplinary Studies

Background:

  • Metastasis presents a significant challenge in cancer research.
  • Understanding the complex mechanisms of cancer spread is crucial for effective treatment.

Discussion:

  • Interdisciplinary research, particularly involving physics, offers novel perspectives on metastasis.
  • Collaboration between different scientific fields can illuminate previously unrecognized aspects of cancer progression.

Key Insights:

  • Physics principles can be applied to model and understand cellular migration and tissue invasion during metastasis.
  • The workshop demonstrated the value of cross-disciplinary thinking in addressing complex biological problems.

Outlook:

  • Continued interdisciplinary collaboration is essential for future breakthroughs in metastasis research.
  • Integrating diverse scientific approaches will accelerate the development of targeted therapies for metastatic cancer.