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Related Concept Videos

Oogenesis02:07

Oogenesis

64.0K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
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Updated: Aug 29, 2025

Fertility Preservation in Patients with Severe Ovarian Dysfunction
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Agonist triggering in oocyte donation programs-Mini review.

Robert Najdecki1, Georgios Michos1, Nikos Peitsidis1

  • 1Assisting Nature, Centre of Assisted Reproduction and Genetics, Thessaloniki, Greece.

Frontiers in Endocrinology
|September 12, 2022
PubMed
Summary
This summary is machine-generated.

Gonadotropin-releasing hormone agonist (GnRH-a) triggering significantly reduces ovarian hyperstimulation syndrome (OHSS) in oocyte donation, improving donor safety. While effective, careful stimulation is still needed to prevent OHSS entirely.

Keywords:
OHSS-free programsagonist triggeringimpact on acceptor’s pregnancy outcomeoocyte donation programsoptimal dose for agonist triggering

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Area of Science:

  • Reproductive Endocrinology
  • Assisted Reproductive Technology

Background:

  • Oocyte donation requires ovarian stimulation, historically associated with Ovarian Hyperstimulation Syndrome (OHSS).
  • Previous protocols often led to severe OHSS complications, necessitating hospitalization.

Purpose of the Study:

  • To evaluate the efficacy and safety of using gonadotropin-releasing hormone agonist (GnRH-a) as a trigger in oocyte donation cycles.
  • To assess the impact of GnRH-a triggering on OHSS incidence and treatment outcomes compared to traditional methods.

Main Methods:

  • Utilizing the short antagonist protocol for ovarian stimulation.
  • Replacing beta-human chorionic gonadotropin (b-hCG) with GnRH-a for final oocyte maturation triggering.

Main Results:

  • GnRH-a triggering significantly reduced moderate to severe OHSS, decreasing hospitalization rates.
  • Oocyte retrieval, fertilization, blastulation, and pregnancy rates were comparable to hCG-triggered cycles.
  • The short antagonist protocol combined with GnRH-a is patient-friendly and safer.

Conclusions:

  • GnRH-a is now the preferred trigger agent in oocyte donation due to its safety and efficacy in preventing OHSS.
  • While GnRH-a greatly reduces OHSS risk, cautious ovarian stimulation remains crucial for donor well-being and treatment success.