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The roles and mechanisms of epigenetic regulation in pathological myocardial remodeling

Kun Zhao1, Yukang Mao1, Yansong Li1

  • 1Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Frontiers in Cardiovascular Medicine
|September 12, 2022
PubMed

Insights

Epigenetic modifications like DNA methylation and RNA modification play crucial roles in pathological myocardial remodeling, a leading cause of death. Understanding these epigenetic mechanisms offers potential new therapeutic targets for heart disease.

Area of Science:

  • Cardiovascular Science
  • Epigenetics
  • Molecular Biology

Background:

  • Pathological myocardial remodeling is a major global health concern with limited treatment options.
  • Epigenetic alterations are increasingly recognized as significant contributors to cardiovascular diseases.

Purpose of the Study:

  • To review recent advancements in understanding epigenetic regulation in pathological myocardial remodeling.
  • To explore the mechanisms underlying the involvement of various epigenetic factors in cardiac remodeling.

Main Methods:

  • Comprehensive literature review of epigenetic mechanisms in pathological myocardial remodeling.
  • Analysis of studies focusing on DNA methylation, histone modifications, chromatin remodeling, non-coding RNAs, and RNA modifications.

Main Results:

  • Detailed summary of key epigenetic regulatory pathways implicated in myocardial remodeling.
  • Identification of specific epigenetic modifications and their roles in cardiac disease progression.

Conclusions:

  • Epigenetic regulation is a critical determinant of pathological myocardial remodeling.
  • Emerging epigenetic targets hold promise for future therapeutic strategies in cardiovascular medicine.

Keywords:
DNA methylationRNA modificationadenosine disodium triphosphate (ATP)-dependent chromatin remodelingepigenetic regulationhistone posttranslational modificationpathological myocardial remodeling

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