Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Design and Optimization of Indomethacin Nanocrystals using Machine Learning and Molecular Dynamics Simulations.

AAPS PharmSciTech·2026
Same author

Optimization of amino acid composition in CHO cell perfusion medium using definitive screening design and <sup>1</sup>H NMR-based consumption profiling.

Biotechnology progress·2025
Same author

Micro-Flow Imaging: Enhanced Precision in Clarity Assessment of Traditional Chinese Medicine TCM Injections Compared to Light Obscuration and Visual Inspection.

AAPS PharmSciTech·2025
Same author

Investigation of Rheological Properties of Molten Materials for Dripping Pills Based on Imaging Monitoring.

Phytochemical analysis : PCA·2024
Same author

An effective and comprehensive optimization strategy for preparing Ginkgo biloba leaf extract enriched in shikimic acid by macroporous resin column chromatography.

Phytochemical analysis : PCA·2024
Same author

Characterisation and critical processes identification for production of herbal preparations using <sup>1</sup>H-NMR and chemometrics: A case study of Trichosanthis Pericarpium injection.

Phytochemical analysis : PCA·2024

Related Experiment Video

Updated: Aug 29, 2025

Measuring Spray Droplet Size from Agricultural Nozzles Using Laser Diffraction
08:14

Measuring Spray Droplet Size from Agricultural Nozzles Using Laser Diffraction

Published on: September 16, 2016

17.2K

Real-time droplet size analysis using laser micrometer as a process analytical technology tool for continuous

Xiaoping Wang1,2, Ying Tian1,2, Sheng Zhang1,2

  • 1Pharmaceutical Informatics Institute College of Pharmaceutical Sciences Zhejiang University Hangzhou China.

Engineering in Life Sciences
|September 12, 2022
PubMed
Summary

A novel laser detection system accurately monitors dripping pill manufacturing. This non-destructive technology ensures high accuracy and efficiency in process analysis and monitoring for pharmaceutical production.

Keywords:
Ginkgo biloba leaf dripping pillsdripping processlaser detection systemon‐line process analysis and monitoring

More Related Videos

High Throughput Analysis of Liquid Droplet Impacts
09:00

High Throughput Analysis of Liquid Droplet Impacts

Published on: March 6, 2020

6.6K
Fabrication and Characterization of Thickness Mode Piezoelectric Devices for Atomization and Acoustofluidics
10:39

Fabrication and Characterization of Thickness Mode Piezoelectric Devices for Atomization and Acoustofluidics

Published on: August 5, 2020

7.0K

Related Experiment Videos

Last Updated: Aug 29, 2025

Measuring Spray Droplet Size from Agricultural Nozzles Using Laser Diffraction
08:14

Measuring Spray Droplet Size from Agricultural Nozzles Using Laser Diffraction

Published on: September 16, 2016

17.2K
High Throughput Analysis of Liquid Droplet Impacts
09:00

High Throughput Analysis of Liquid Droplet Impacts

Published on: March 6, 2020

6.6K
Fabrication and Characterization of Thickness Mode Piezoelectric Devices for Atomization and Acoustofluidics
10:39

Fabrication and Characterization of Thickness Mode Piezoelectric Devices for Atomization and Acoustofluidics

Published on: August 5, 2020

7.0K

Area of Science:

  • Pharmaceutical Manufacturing
  • Process Analytical Technology
  • Optical Sensing

Background:

  • Process analysis and monitoring are crucial in dripping pill manufacturing.
  • Limited development exists for sensor-based or process analytical technology (PAT) tools for this process.

Purpose of the Study:

  • To develop a fast, non-destructive laser detection system for quantitative visualization of droplets.
  • To enable accurate detection of droplet size and calculation of dripping pill weight during manufacturing.

Main Methods:

  • Exploration of factors influencing detection performance.
  • Assessment of the system's capability for quantitative pill weight determination.
  • Application of the laser detection system on a production line.

Main Results:

  • The laser detection system achieved high accuracy in detecting dripping pill weight (R² > 0.99).
  • The system demonstrated robustness against variations in critical process parameters and material attributes.
  • Successful implementation on a Ginkgo biloba leaf dripping pill production line.

Conclusions:

  • The developed laser detection system provides stable, accurate, and efficient analysis and monitoring of the dripping pill manufacturing process.
  • This technology offers a valuable tool for quality control and process optimization in pharmaceutical production.
  • The non-destructive nature of the laser system enhances its applicability in real-time manufacturing environments.