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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Cutaneous involvement in relapsed multiple myeloma.

Valéry Salle¹, Christophe Attencourt², Marion Chevalier¹

¹Department of Internal Medicine Amiens University Hospital Amiens France.

Clinical Case Reports

|September 12, 2022

Summary

This summary is machine-generated.

Cutaneous involvement is a rare manifestation of multiple myeloma. This case highlights a refractory patient with a unique dermal plasma cell infiltrate, indicating an aggressive disease course.

Keywords:

cutaneous involvement extramedullary disease immature plasma cells multiple myeloma

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An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

Published on: July 15, 2015

Area of Science:

Hematology
Oncology
Dermatology

Background:

Multiple myeloma is a hematologic malignancy characterized by malignant plasma cells.
Extramedullary disease (EMD) in multiple myeloma signifies advanced disease and is associated with a poorer prognosis.
Cutaneous involvement in multiple myeloma with EMD is exceptionally rare.

Observation:

A patient with refractory multiple myeloma presented with a novel cutaneous lesion.
Histopathological examination of the lesion revealed immature plasma cell infiltration within the dermis.
Immunohistochemical analysis showed a notable absence of CD138 expression on these plasma cells.

Findings:

The rare cutaneous manifestation in this refractory multiple myeloma case was characterized by immature plasma cells lacking CD138.
This specific extramedullary site correlated with a clinically aggressive disease progression.
The patient experienced a significantly shortened survival period following the development of the cutaneous lesion.

Implications:

This case expands the understanding of the diverse clinical presentations of multiple myeloma.
The lack of CD138 expression in cutaneous plasma cells may represent a distinct biological feature.
Identifying rare extramedullary disease sites is crucial for prognostication and management of refractory multiple myeloma.