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CT imaging features of paranasal sinuses in children with primary ciliary dyskinesia

Huiying Lyu1, Zhuoyao Guo2, Chao Chen1

  • 1Department of Otolaryngology-Head and Neck Surgery, Children's Hospital of Fudan University, Shanghai, China.

Acta Oto-Laryngologica
|September 12, 2022
PubMed

Insights

Primary ciliary dyskinesia (PCD) in children shows similar rhinosinusitis severity to controls, but this severity decreases with age. This study highlights a novel inverse correlation between age and radiographic rhinosinusitis in pediatric PCD patients.

Area of Science:

  • Pediatric Radiology
  • Otolaryngology
  • Pulmonology

Background:

  • Primary ciliary dyskinesia (PCD) is a genetic disorder impairing mucociliary clearance, leading to chronic respiratory and sinonasal issues.
  • Children with PCD often present with recurrent sinonasal infections and inflammation.

Purpose of the Study:

  • To investigate the computed tomography (CT) imaging characteristics of paranasal sinuses in pediatric patients diagnosed with PCD.
  • To evaluate the correlation between age and the severity of rhinosinusitis in children with PCD.

Main Methods:

  • A cohort of 17 pediatric PCD patients (ages 4-13) underwent CT scans of the paranasal sinuses.
  • Scoring of sinus inflammation was performed using the Lund-Mackay staging system.
  • A control group of non-PCD chronic rhinosinusitis (CRS) patients was included for comparison.

Main Results:

  • All PCD patients exhibited signs of rhinosinusitis on CT scans.
  • The mean Lund-Mackay score in PCD patients was comparable to the non-PCD CRS control group (14.2 vs. 14.6, p=0.79).
  • A significant inverse correlation was observed between patient age and Lund-Mackay score in PCD patients (r=-0.530, p=0.029), indicating reduced radiographic severity with increasing age.

Conclusions:

  • Radiographic severity of rhinosinusitis in pediatric PCD patients is similar to that in non-PCD CRS patients.
  • A notable finding is the inverse relationship between age and rhinosinusitis severity in children with PCD, suggesting a potential natural improvement or altered disease progression over time.
Abstract

Keywords:
Lund–MackayPrimary ciliary dyskinesiacomputed tomographyrespiratory distresssinusitis

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