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Related Experiment Video

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Brain Imaging Investigation of the Memory-Enhancing Effect of Emotion
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Homocysteine Modulates Brain Functional Connectivity in a Memory Retrieval Task.

Richard B Silberstein1,2, Andrew Pipingas1, Andrew B Scholey1

  • 1Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, VIC, Australia.

Journal of Alzheimer'S Disease : JAD
|September 12, 2022
PubMed
Summary
This summary is machine-generated.

High homocysteine levels correlate with altered brain connectivity in men at risk for cognitive decline. This link is evident at concentrations above 11μmol/L, suggesting homocysteine impacts brain function.

Keywords:
Brain functional connectivitycognitive declinehomocysteinememory

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Area of Science:

  • Neuroscience
  • Metabolic Health
  • Cognitive Aging

Background:

  • Homocysteine, a metabolite of methionine, is linked to cognitive decline and dementia.
  • Early stages of age-related cognitive decline show increased brain activity and functional connectivity.

Purpose of the Study:

  • To investigate the relationship between plasma homocysteine levels and brain functional connectivity.
  • Focus on late middle-aged males at risk for cognitive decline due to BMI and sedentary lifestyle.

Main Methods:

  • Measured brain functional connectivity using steady state visual evoked potential (SSVEP) event-related partial coherence.
  • Participants (n=38) performed object recognition and location memory tasks.

Main Results:

  • A transient peak in correlation between homocysteine and fronto-parietal brain functional connectivity was observed before the location memory task.
  • This correlation was significant only in participants with homocysteine levels > 11μmol/L.

Conclusions:

  • Increased brain functional connectivity in early cognitive decline may represent pathological changes, not compensatory mechanisms.
  • Homocysteine may impair cortical network inhibition necessary for optimal task performance.
  • The effect of homocysteine on brain connectivity is apparent at concentrations above 11μmol/L.