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Updated: Aug 29, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Photo-induced metal-free dehydrogenative N-N homo-coupling
Bugga Balakrishna1, Susanne Mossin1, Søren Kramer1
1Department of Chemistry, Technical University of Denmark, 2800, Kgs. Lyngby, Denmark. sokr@kemi.dtu.dk.
Abstract:
We report a photo-induced dehydrogenative N-N coupling of diarylimines, diarylamines, carbazoles, and anilines. These homo-coupling reactions require only the combination of readily available di-tert-butyl peroxide (DTBP) and light irradition. The operationally simple protocol works under catalyst- and metal-free conditions and exhibits a good substrate scope. Preliminary mechanistic studies indicate that the reaction proceeds via photo-induced homolytic cleavage of the peroxide followed by hydrogen atom transfer leading to the formation of N-centered radicals.
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