Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthetic Biology02:55

Synthetic Biology

4.9K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
4.9K
Recombinant DNA01:09

Recombinant DNA

96.4K
Overview
96.4K
Viral Recombination00:57

Viral Recombination

23.7K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
23.7K
Reproductive Cloning01:27

Reproductive Cloning

30.7K
Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by splitting an early embryo—similar to what happens naturally with identical twins—cloning of adult animals is usually done by a process called somatic cell nuclear transfer (SCNT).
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic...
30.7K
Replication in Eukaryotes02:31

Replication in Eukaryotes

171.4K
Overview
171.4K
Replication in Prokaryotes02:35

Replication in Prokaryotes

88.2K
Overview
88.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Leptin: 30 Years Later.

Annual review of physiology·2025
Same author

Drug Development Failure: How GLP-1 Development Was Abandoned in 1990.

Perspectives in biology and medicine·2024
Same author

Politicizing science funding undermines public trust in science, academic freedom, and the unbiased generation of knowledge.

Frontiers in research metrics and analytics·2024
Same author

Publishing Biomedical Research: <i>a rapidly evolving ecosystem</i>.

Perspectives in biology and medicine·2024
Same author

The Diversity of Institutions Conducting Biomedical Research.

Perspectives in biology and medicine·2024
Same author

Leptin physiology and pathophysiology: knowns and unknowns 30 years after its discovery.

The Journal of clinical investigation·2024

Related Experiment Video

Updated: Aug 29, 2025

Author Spotlight: Biological Standardization to Ensure Reproducibility and Harmonization in Research
04:50

Author Spotlight: Biological Standardization to Ensure Reproducibility and Harmonization in Research

Published on: August 4, 2023

1.2K

The Problem of Irreproducible Bioscience Research.

Jeffrey S Flier

    Perspectives in Biology and Medicine
    |September 12, 2022
    PubMed
    Summary

    A significant portion of bioscience research is irreproducible, impacting scientific progress. This review explores the causes of irreproducibility and proposes interventions to enhance research reliability and investment efficiency.

    Area of Science:

    • Bioscience Research
    • Scientific Reproducibility

    Background:

    • Despite remarkable advances in bioscience, a high fraction of published research faces reproducibility challenges.
    • Irreproducibility is a growing concern, necessitating analysis, understanding, and remediation within the scientific community.

    Purpose of the Study:

    • To review the definition and prevalence of research reproducibility.
    • To examine factors contributing to irreproducibility in bioscience.
    • To explore potential interventions for improving research reliability.

    Main Methods:

    • Literature review on research reproducibility.
    • Analysis of factors contributing to irreproducibility.
    • Examination of case studies on irreproducible findings.
    • Discussion of potential interventions.

    More Related Videos

    Reproducible dsRNA Microinjection and Oviposition Bioassay in Mosquitoes and House Flies
    08:41

    Reproducible dsRNA Microinjection and Oviposition Bioassay in Mosquitoes and House Flies

    Published on: November 8, 2018

    8.9K
    The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan
    11:58

    The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan

    Published on: June 29, 2018

    9.5K

    Related Experiment Videos

    Last Updated: Aug 29, 2025

    Author Spotlight: Biological Standardization to Ensure Reproducibility and Harmonization in Research
    04:50

    Author Spotlight: Biological Standardization to Ensure Reproducibility and Harmonization in Research

    Published on: August 4, 2023

    1.2K
    Reproducible dsRNA Microinjection and Oviposition Bioassay in Mosquitoes and House Flies
    08:41

    Reproducible dsRNA Microinjection and Oviposition Bioassay in Mosquitoes and House Flies

    Published on: November 8, 2018

    8.9K
    The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan
    11:58

    The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan

    Published on: June 29, 2018

    9.5K

    Main Results:

    • A significant fraction of published bioscience research is potentially irreproducible.
    • Multiple factors contribute to the issue, including experimental and interpretive errors.
    • Case studies reveal varied researcher responses to claims of irreproducibility.

    Conclusions:

    • Irreproducibility poses a serious threat to the efficiency and impact of bioscience research.
    • Interventions are needed to improve the reliability of scientific findings.
    • Addressing irreproducibility is crucial for maximizing societal investment in research.