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Related Experiment Video

Updated: Aug 29, 2025

An Air-liquid Interface Bronchial Epithelial Model for Realistic, Repeated Inhalation Exposure to Airborne Particles for Toxicity Testing

An Air-liquid Interface Bronchial Epithelial Model for Realistic, Repeated Inhalation Exposure to Airborne Particles for Toxicity Testing

Published on: May 13, 2020

Talc Inhalation in Rats and Humans: A Review and Appraisal of Available Evidence.

Paul J A Borm¹

¹From the Nanoconsult Holding BV, Meerssen (NL).

Journal of Occupational and Environmental Medicine

|September 12, 2022

Summary

Talc exposure may cause specific target organ toxicity (STOT-RE). Inhalation studies and talc miner data support a STOT-RE 1 classification due to pulmonary effects.

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Area of Science:

Toxicology
Inhalation Toxicology
Occupational Health

Background:

Current toxicological data suggest talc may cause specific target organ toxicity from repeated exposure (STOT-RE).
This study assesses available inhalation toxicity data for talc.

Approach:

A comprehensive database of 177 articles was compiled.
Animal inhalation studies underwent quality review, and recent epidemiological studies on talc and lung effects were analyzed.

Key Points:

Only one of nine reviewed inhalation studies met criteria for reliable STOT-RE evaluation.
Pulmonary effects observed in talc miners align with STOT-RE classification.

Conclusions:

A STOT-RE 1 classification is warranted for talc based on inhalation toxicity data and occupational exposure findings.