The relationship between nondipper hypertension and triglyceride glucose index

Area of Science:

• Cardiology
• Endocrinology
• Nephrology

Background:

• Nondipper hypertension is associated with increased end-organ damage and poorer cardiovascular prognosis.
• The triglyceride glucose (TyG) index is a validated marker for insulin resistance and cardiovascular risk.
• The relationship between the TyG index and abnormal diurnal blood pressure patterns remains unexplored.

Purpose of the Study:

• To investigate the association between the TyG index and nondipper hypertension.
• To compare the TyG index in normotensive, dipper hypertensive, and nondipper hypertensive individuals.

Main Methods:

• Ambulatory blood pressure monitoring was used to classify 1037 patients into dipper hypertensive, nondipper hypertensive, and normotensive groups.
• Univariate and multivariate logistic regression analyses identified predictors of nondipper hypertension.
• Receiver operating characteristic (ROC) curve analysis determined the predictive value of the TyG index.

Main Results:

• The TyG index was identified as an independent predictor of nondipper hypertension (OR, 4.656; P < 0.001).
• Age and glomerular filtration rate (GFR) were also independent predictors of nondipper hypertension.
• A TyG index cutoff of ≥4.74 showed 59.7% sensitivity and 59.9% specificity for predicting nondipper hypertension (AUC = 0.647).

Conclusions:

• The TyG index, along with age and GFR, independently predicts nondipper hypertension.
• The TyG index offers a simple, cost-effective method for identifying individuals with the nondipper blood pressure pattern in essential hypertension.