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Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Related Experiment Video

Updated: Aug 29, 2025

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
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Corneal Crosslinking: Present and Future.

Lize Angelo1, Akilesh Gokul Boptom, Charles McGhee

  • 1Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Asia-Pacific Journal of Ophthalmology (Philadelphia, Pa.)
|September 12, 2022
PubMed
Summary

Corneal crosslinking (CXL) effectively halts progressive keratoconus, reducing the need for corneal transplants. This treatment is also being explored for other eye conditions.

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Area of Science:

  • Ophthalmology
  • Corneal Science
  • Vision Science

Background:

  • Keratoconus is a progressive corneal disease causing vision loss.
  • Corneal crosslinking (CXL) has become a standard treatment for keratoconus.
  • CXL halts disease progression and reduces keratoplasty rates.

Purpose of the Study:

  • To review the current applications of CXL in keratoconus.
  • To explore the expanding uses of CXL in other ocular conditions.
  • To provide insights into future advancements in CXL therapy.

Main Methods:

  • Literature review of corneal crosslinking studies.
  • Analysis of CXL efficacy in keratoconus management.
  • Evaluation of CXL's role in combination therapies and other pathologies.

Main Results:

  • CXL is a proven method to stabilize keratoconus progression.
  • CXL is increasingly used in combination treatments for improved visual outcomes.
  • Extrapolation of CXL for treating myopia, keratitis, and bullous keratopathy shows promise.

Conclusions:

  • Corneal crosslinking is a cornerstone in modern keratoconus management.
  • The therapeutic potential of CXL is expanding beyond its primary indication.
  • Future research will likely focus on refining CXL techniques and applications.