Related Experiment Video
Updated: Aug 29, 2025
06:52
Behavioral and Locomotor Measurements Using an Open Field Activity Monitoring System for Skeletal Muscle Diseases
Published on: September 29, 2014
53.9K
Anti-MDA5 dermatomyositis: an update from bench to bedside
Enrico Fuzzi1, Mariele Gatto, Margherita Zen
1Division of Rheumatology, Department of Medicine DIMED, Padua University Hospital, Padua, Italy.
Current Opinion in Rheumatology
|September 12, 2022
Summary
This review covers anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis, focusing on interstitial lung disease. Early immunosuppression is crucial for survival in patients with acute lung involvement.
Area of Science:
- Rheumatology
- Immunology
- Pulmonology
Background:
- Anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis presents a complex clinical spectrum.
- Interstitial lung disease (ILD) is a significant and often severe complication associated with anti-MDA5+ dermatomyositis.
Purpose of the Study:
- To review recent advancements in understanding anti-MDA5 antibody-positive dermatomyositis.
- To focus on the pathogenesis, clinical manifestations, and treatment strategies for rapidly progressive ILD in this condition.
Main Methods:
- Literature review of recent developments in anti-MDA5 antibody-positive dermatomyositis.
- Synthesis of information on pathogenesis, clinical features, and treatment of ILD.
Main Results:
- Anti-MDA5+ dermatomyositis exhibits a heterogeneous clinical spectrum with varying patient outcomes.
- Severe acute interstitial lung disease is the primary determinant of prognosis.
- The pathogenetic role of anti-MDA5 antibodies is under active investigation.
Conclusions:
- A high index of suspicion is necessary to diagnose atypical presentations of anti-MDA5+ dermatomyositis.
- Aggressive treatment with early combined immunosuppression offers the best survival chances for patients with acute interstitial lung involvement.
Related Concept Videos
01:14Myocarditis III: Medical Management
13
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
13
01:20Myasthenia Gravis: Overview and Treatment
1.8K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.8K
01:22Myocarditis IV: Nursing Management
17
Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...
17
01:27Myocarditis II: Clinical Features and Diagnostic Tests
19
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
19
01:21Myocarditis I: Introduction
23
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
23
01:17Pericarditis III: Medical Management
22
The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
22