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The PCI domains are "winged" HEAT domains
Eleanor Elise Paul1, Assen Marintchev1
1Department of Physiology & Biophysics, Boston University School of Medicine, Boston, Massachusetts, United States of America.
Plos One
|September 12, 2022
Summary
Protein domains called HEAT and PCI share structural similarities, suggesting PCI domains evolved from HEAT domains by acquiring a winged-helix subdomain. This finding reclassifies PCI domains as part of the larger HEAT domain family.
Area of Science:
- Structural biology
- Protein domain evolution
- Molecular biology
Background:
- HEAT domains are helical hairpin repeat domains involved in diverse cellular processes.
- PCI domains are related helical hairpin domains with a winged-helix subdomain crucial for complex formation.
- Current classification considers HEAT and PCI domains as separate, though related, families.
Purpose of the Study:
- To investigate the structural relationship between HEAT and PCI domains.
- To determine if PCI domains represent a subgroup within the HEAT domain family.
- To elucidate the evolutionary origins of PCI domains.
Main Methods:
- Extensive structure similarity analysis of HEAT and PCI domains.
- Comparative analysis of structural similarities within and between domain groups.
- Utilizing structure similarity searches to identify relationships.
Main Results:
- PCI domains exhibit significant structural similarity to certain HEAT domain groups.
- Structural similarity between PCI domains and some HEAT domains exceeds similarities among certain HEAT domain groups.
- Evidence suggests PCI domains evolved from a HEAT domain that acquired a winged-helix subdomain.
Conclusions:
- PCI domains are likely a specialized subgroup of the HEAT domain family.
- The acquisition of a winged-helix subdomain in HEAT domains led to the evolution of PCI domains.
- This evolutionary path explains the formation of multi-subunit complexes like the Proteasome lid, COP9 signalosome, and eIF3.
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