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Training-induced hypoalgesia and its potential underlying mechanisms
Jun Seob Song1, Yujiro Yamada1, Ryo Kataoka1
1Department of Health, Exercise Science, and Recreation Management. Kevser Ermin Applied Physiology Laboratory, The University of Mississippi, MS, USA.
Neuroscience and Biobehavioral Reviews
|September 12, 2022
Summary
Repeated exercise training may reduce pain sensitivity in chronic pain patients, unlike single exercise bouts. Further research is needed to understand training-induced hypoalgesia mechanisms.
Area of Science:
- Exercise science
- Pain research
- Neuroimmunology
Background:
- Single exercise bouts induce hypoalgesia in healthy individuals.
- This effect is often diminished in chronic pain populations.
- Repeated exercise (training) may be necessary for chronic pain hypoalgesia.
Purpose of the Study:
- Review existing literature on training-induced hypoalgesia.
- Discuss potential underlying mechanisms.
- Identify future research directions.
Main Methods:
- Literature review of training-induced hypoalgesia.
- Analysis of studies investigating exercise training and pain sensitivity.
- Exploration of central nervous system and immune system roles.
Main Results:
- Training interventions show potential for hypoalgesic adaptations.
- Central nervous system and immune system factors may be involved.
- Limited randomized controlled trials exist.
Conclusions:
- Exercise training may offer a strategy for pain management in chronic pain.
- Mechanisms underlying training-induced hypoalgesia require further investigation.
- More high-quality research, including RCTs, is warranted.
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