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Ochratoxin A induced differentiation nephrotoxicity in renal tubule and glomeruli via autophagy differential

Guannan Le1, Heng Du2, Ardache Sylia2

  • 1Southeast University, Nanjing 211189, China; College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, Jiangsu, China; Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China.

Environmental Toxicology and Pharmacology
|September 12, 2022
PubMed

Insights

Ochratoxin A (OTA) causes kidney damage, with higher toxicity observed in renal tubules than glomeruli. This differential nephrotoxicity is linked to autophagy regulation.

Area of Science:

  • Toxicology
  • Nephrology
  • Cell Biology

Background:

  • Ochratoxin A (OTA) is a mycotoxin known for its nephrotoxic effects.
  • While OTA's impact on glomeruli and renal tubules is documented, a direct comparison of its toxicity between these kidney structures is lacking.

Purpose of the Study:

  • To investigate the differential nephrotoxicity of Ochratoxin A (OTA) on glomeruli and renal tubules.
  • To explore the role of autophagy in OTA-induced kidney damage.

Main Methods:

  • In vivo studies using C57BL/6 mice exposed to varying concentrations of OTA.
  • In vitro studies using two types of nephrocytes treated with OTA.
  • Analysis of kidney function, cell viability, pathological sections, and autophagy signaling.

Main Results:

  • OTA induced nephrotoxicity in mice and reduced nephrocyte viability in vitro.
  • Renal tubules exhibited higher sensitivity to OTA toxicity compared to glomeruli.
  • OTA exposure modulated autophagy signaling, indicating its involvement in differential nephrotoxicity.

Conclusions:

  • Ochratoxin A causes differentiation-dependent nephrotoxicity in glomeruli and renal tubules.
  • Autophagy plays a significant role in the differential regulation of OTA-induced kidney damage.
Keywords:
AutophagyGlomeruliNephrotoxicityOchratoxin ARenal tubules

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