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Updated: Aug 29, 2025

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model
Published on: March 16, 2022
Diagnostic Imaging of Diabetic Foot Disorders
Keivan Daneshvar1, Helen Anwander2
1Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 18, 3010 Bern, Switzerland.
Abstract:
Plain, weight-bearing radiography is the preferred first-line imaging. Dependent on the suspected pathology, further imaging is indicated. In a soft tissue infection, an abscess has to be excluded, for example, with ultrasound. Osteomyelitis has a typical triad including osteolysis, periosteal reaction, and bone destruction in radiography, but signs are often delayed. MRI is the gold standard for diagnosis of osteomyelitis with high intensity in T2-weighted and STIR images and intermediate to decreased reticulated hazy intensity in T1-weighted images. In comparison, bone marrow edema is also bright on the T2-weighted image but the T1-weighted image has a confluent low intensity.
Insights
Plain radiography is the initial choice for imaging, but advanced techniques like ultrasound and MRI are crucial for diagnosing soft tissue infections and osteomyelitis, respectively. MRI offers superior detail for definitive osteomyelitis diagnosis.
Area of Science:
- Radiology
- Medical Imaging
- Orthopedics
Background:
- Plain radiography is the standard initial imaging modality.
- Further imaging is necessary based on suspected pathology.
- Early signs of osteomyelitis can be delayed on radiography.
Purpose of the Study:
- To outline the role of various imaging modalities in diagnosing bone and soft tissue infections.
- To highlight the diagnostic capabilities of MRI for osteomyelitis.
Main Methods:
- Review of imaging techniques for soft tissue infections and osteomyelitis.
- Description of radiographic findings (osteolysis, periosteal reaction, bone destruction).
- Explanation of MRI sequences (T2-weighted, STIR, T1-weighted) for osteomyelitis detection.
Main Results:
- Ultrasound is used to exclude abscesses in soft tissue infections.
- Radiography shows delayed signs of osteomyelitis.
- MRI is the gold standard, differentiating osteomyelitis from bone marrow edema based on signal intensities in T1 and T2 weighted images.
Conclusions:
- Imaging selection depends on the suspected condition.
- MRI provides definitive diagnosis for osteomyelitis.
- Understanding MRI signal characteristics is key for accurate diagnosis.
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