Endogenous serotonin release from rat cerebellar slices
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Published on: January 18, 2019
General Pharmacology
|January 1, 1987
Abstract:
Endogenous serotonin (5-HT) content in cerebellar slices and in the incubation medium was measured before and after depolarizing stimulus with high-K+ concentration in the medium. Small amount of 5-HT was spontaneously released from tissue slices incubated in low-K+ and Ca2+-free medium. A significant increase of endogenous 5-HT release was obtained after depolarizing stimulus with high-K+ plus Ca2+ in the medium. It is suggested that the endogenous 5-HT release in cerebellum induced by depolarizing stimuli is a Ca2+-dependent phenomenon.
