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Updated: Aug 29, 2025

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
Published on: July 24, 2019
Basal ganglia engagement during REM sleep movements in Parkinson's disease
Ajay K Verma1, Sergio Francisco Acosta Lenis1, Joshua E Aman1
1Department of Neurology, University of Minnesota, Minneapolis, MN, USA.
Abstract:
To elucidate the role of the basal ganglia during REM sleep movements in Parkinson's disease (PD) we recorded pallidal neural activity from four PD patients. Unlike desynchronization commonly observed during wakeful movements, beta oscillations (13-35 Hz) synchronized during REM sleep movements; furthermore, high-frequency oscillations (150-350 Hz) synchronized during movement irrespective of sleep-wake states. Our results demonstrate differential engagement of the basal ganglia during REM sleep and awake movements.
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