A comprehensive review on methotrexate containing nanoparticles; an appropriate tool for cancer treatment
Hanifeh Shariatifar1, Fateme Ranjbarian2, Fahimeh Hajiahmadi3
1Health Products Safety Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
Abstract:
For more than seven decades, methotrexate has been used all over the world for treatment of different diseases such as: cancer, autoimmune diseases, and rheumatoid arthritis. Several studies have addressed its formula, efficacy, and delivery methods in recent years. These studies have been focused on the effectiveness of different nanoparticles on drug delivery, delivery of the drug to the target cells, and attenuation of harm to the host cell. Whereas, the main usages of methotrexate are in cancer treatment field, this review provided a brief perspective into using different nanoparticles and their role in the treatment of different cancers.
Related Concept Videos
Drugs that Stabilize Microtubules
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Drugs that Destabilize Microtubules
Treatment Resistent Cancers
Therapeutic Drug Monitoring: Affecting Factors


