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Substitution rates under stabilizing selection.

A Hastings

    Genetics
    |July 1, 1987
    PubMed
    Summary

    This study shows that strong selection significantly slows down genetic substitutions in quantitative traits. The rate of these genetic changes per locus also depends heavily on the number of loci involved.

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    Area of Science:

    • Population Genetics
    • Quantitative Genetics
    • Evolutionary Biology

    Background:

    • Understanding genetic substitutions is key to explaining evolutionary change.
    • Stabilizing selection on quantitative traits plays a crucial role in maintaining optimal phenotypes.

    Purpose of the Study:

    • To investigate the impact of stabilizing selection on the rate of allelic substitutions.
    • To compare simulation results with analytical models for different numbers of loci.

    Main Methods:

    • Monte Carlo simulations were performed using 8 and 16 loci.
    • Results were compared to analytical models, including those for two and 'infinite' loci.
    • Selection strengths (S = 4Nes) were set to approximately four, representing realistic selection pressures.

    Main Results:

    • Strong selection (S ≈ 4) can reduce substitution rates by up to tenfold compared to neutral evolution.
    • A significant dependence of per-locus substitution rates on the total number of loci was observed.
    • Simulation results align with and extend analytical predictions.

    Conclusions:

    • Stabilizing selection on quantitative traits substantially retards the rate of genetic substitutions.
    • The number of loci involved is a critical factor influencing substitution rates in selection scenarios.
    • These findings have implications for understanding the tempo and mode of evolution for complex traits.

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