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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
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Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Articles linked to this work by shared authors, journal, and citation graph.

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2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis: Treatment of Asymptomatic Histoplasma Pulmonary Nodules (Histoplasmomas) and Mild or Moderate Acute Pulmonary Histoplasmosis in Adults, Children, and Pregnant People.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2025
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2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis: Treatment of Mild or Moderate Acute Pulmonary Histoplasmosis in Adults, Children, and Pregnant People.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2025
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2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis: Treatment of Asymptomatic Histoplasma Pulmonary Nodules (Histoplasmomas) in Adults, Children, and Pregnant People.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2025
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The tell-tale hearts: Donor-derived invasive fungal infections among orthotopic heart transplant recipients.

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A change of heart: Limitations of National Healthcare Safety Network (NHSN) and Society of Thoracic Surgeons (STS) surveillance strategies in identifying surgical site infections after heart transplant surgery.

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Contemporary Cytomegalovirus (CMV) Infections in Low-Risk CMV Seronegative Recipients of Solid Organ Transplants From CMV Seronegative Donors (D-/R-): Time to Reexamine Donor CMV Serostatus.

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Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens
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Updates on Histoplasmosis in Solid Organ Transplantation.

Jennifer L Saullo1, Rachel A Miller2

  • 1Department of Medicine, Division of Infectious Diseases, Duke University School of Medicine, Duke University Medical Center, DUMC #102359, Hanes House, Room 252, Durham, NC 27710 USA.

Current Fungal Infection Reports
|September 13, 2022
PubMed
Summary

Histoplasmosis is a growing concern in organ transplant recipients. This review covers updated epidemiology, diagnostics, and treatments for this challenging fungal infection.

Keywords:
Antifungal therapyCOVID-19Endemic mycosesHistoplasmosisImmunocompromisedInfectionSolid organ transplantation

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Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Transplantation Medicine

Background:

  • Histoplasmosis presents significant challenges in solid organ transplantation.
  • Epidemiological shifts and host factors influence disease patterns.

Purpose of the Study:

  • To provide an update on Histoplasmosis in solid organ transplantation.
  • To highlight changes in epidemiology, diagnostics, and treatment.

Main Methods:

  • Review of recent literature on Histoplasmosis.
  • Analysis of epidemiological trends and diagnostic advancements.
  • Evaluation of novel therapeutic strategies.

Main Results:

  • Expanding geographic distribution of Histoplasma due to climate change and environmental disruption.
  • Emerging association between COVID-19 and histoplasmosis in immunocompromised individuals.
  • Advancements in enzyme immunoassays and molecular techniques for rapid pathogen identification.
  • Development of new antifungal formulations, extended-spectrum azoles, and new drug classes.

Conclusions:

  • Despite advances in transplantation, Histoplasmosis management requires ongoing innovation.
  • Emerging insights improve understanding and management of Histoplasmosis, especially in transplant recipients.
  • New diagnostics and therapeutics offer improved options for this severe infection.