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Blood cell parameters do not change during physiological human ageing.

J Corberand, P Laharrague, G Fillola

    Gerontology
    |January 1, 1987
    PubMed
    Summary
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    Hematological values in the elderly are inconsistent due to varying selection criteria. Stringent criteria reveal normal blood cell parameters in healthy aged individuals, confirming the need for rigorous participant selection in gerontology research.

    Area of Science:

    • Gerontology
    • Hematology
    • Biostatistics

    Background:

    • Hematological values in the elderly lack standardized 'normal' ranges, leading to clinical challenges.
    • Discrepancies in reported normal values for aged populations may stem from differing subject selection criteria.
    • Defining 'healthy' in older adults is crucial for accurate physiological assessments.

    Purpose of the Study:

    • To investigate the impact of stringent versus conventional selection criteria on hematological parameters in healthy elderly individuals.
    • To establish reliable reference ranges for blood cell counts in a rigorously defined healthy aged population.
    • To determine if significant hematological alterations are inherent to aging or a result of less strict health criteria.

    Main Methods:

    • Comparison of blood cell parameters between two groups of elderly subjects (>75 years) selected by different criteria (Senieur protocol vs. conventional).

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  • Inclusion of sex-matched young adult controls (20-29 years) for parallel testing.
  • Analysis of standard blood cell counts (e.g., red blood cells, white blood cells, platelets).

    • Main Results:

    • Elderly subjects selected using stringent criteria (Senieur protocol) showed no clinically significant hematological alterations compared to young controls.
    • Elderly subjects recruited with conventional criteria exhibited more pronounced differences in blood cell parameters.
    • Blood cell parameters in Group A (stringent criteria) were consistent with those of young controls, indicating aging itself does not necessitate altered hematology.

    Conclusions:

    • Stringent selection criteria are essential for accurate biological investigations in gerontology.
    • Hematological parameters in the elderly remain stable and unaltered when subjects are truly healthy.
    • The study underscores the importance of robust participant screening to avoid misinterpreting physiological norms in aging research.