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Updated: Aug 29, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Bio-SODA UX: enabling natural language question answering over knowledge graphs with user disambiguation.
Ana Claudia Sima1, Tarcisio Mendes de Farias1,2,3, Maria Anisimova1,4
1SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Bio-SODA is a novel engine for natural language processing over scientific knowledge graphs. It generates SPARQL queries without training data, outperforming existing systems by over 20% F1-score.
Area of Science:
- Computer Science
- Bioinformatics
- Data Science
Background:
- Natural Language Processing (NLP) over structured data is a growing research area.
- Existing Knowledge Graph Question Answering (KGQA) systems often require large training datasets or are domain-specific.
- These limitations hinder their application to complex scientific datasets.
Purpose of the Study:
- To introduce Bio-SODA, an NLP engine for scientific knowledge graphs that does not require training data.
- To enable efficient querying of complex scientific data using natural language.
- To improve the performance of KGQA systems in scientific domains.
Main Methods:
- A generic graph-based approach for translating natural language questions into SPARQL queries.
- A novel ranking algorithm incorporating node centrality for query relevance.
- Implementation of Bio-SODA UX, a graphical user interface for knowledge graph exploration and question disambiguation.
Main Results:
- Bio-SODA successfully generates SPARQL queries without question-answer pair training data.
- Experiments on scientific datasets, including bioinformatics and CORDIS, show significant performance improvements.
- Outperformed publicly available KGQA systems by at least 20% F1-score, with higher gains on complex bioinformatics data.
Conclusions:
- Bio-SODA offers a data-efficient and effective solution for NLP over scientific knowledge graphs.
- The system demonstrates superior performance compared to existing KGQA approaches.
- Bio-SODA and its accompanying UX facilitate broader access and exploration of scientific data.
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