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Four-Dimensional Printing of Stimuli-Responsive Hydrogel-Based Soft Robots

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Programmable 4D Printing of Photoactive Shape Memory Composite Structures.

Yongdie Deng¹, Fenghua Zhang¹, Menglu Jiang²

¹Centre for Composite Materials and Structures, Harbin Institute of Technology (HIT), No. 2 Yikuang Street, Harbin 150000, People's Republic of China.

ACS Applied Materials & Interfaces

|September 13, 2022

Summary

This summary is machine-generated.

Researchers developed 4D printing using smart composites for medical devices. This technology enables light-controlled shape changes for minimally invasive cancer treatments and tissue scaffolds.

Keywords:

4D printing light-active light-thermal therapy shape memory composites smart structure

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Area of Science:

Biomedical Engineering
Materials Science
Nanotechnology

Background:

4D printing merges additive manufacturing with smart materials for dynamic structures.
Smart medical devices require remote control, therapeutic functions, and biocompatibility.
Light-active shape memory composites offer potential for advanced 4D printing applications.

Purpose of the Study:

To develop a multifunctional composite for 4D printing.
To investigate its light-thermal properties for cancer hyperthermia treatment.
To demonstrate the fabrication and function of 4D-printed medical structures.

Main Methods:

Incorporating gold nanoparticles into a shape memory polyurethane matrix.
Characterizing the composite's mechanical properties, biocompatibility, and light-active shape memory performance.
Utilizing direct bioprinting of the composite melt to create 4D structures.

Main Results:

The composite exhibited rapid and stable light-thermal effects for localized tumor ablation.
4D-printed structures showed autonomous, light-driven shape recovery.
Demonstrated potential for fabricating soft tissue and intraluminal scaffolds with shape-changing capabilities.

Conclusions:

A novel light-active shape memory composite was successfully prepared for 4D printing.
The developed material and 4D printing strategy offer a promising approach for minimally invasive cancer therapy.
This technology inspires the creation of customized, light-thermal therapeutic structures for medical applications.