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Comparative study on retinal microvasculature changes between acute and chronic central serous chorioretinopathy
Xiaogang Wang1, Jie Zhang2, Renhe Yu3
1Department of Cataract, Shanxi Eye Hospital, Taiyuan 030002. movie6521@163.com.
Summary
Chronic central serous chorioretinopathy (CSC) significantly reduces deep capillary plexus and inner retina blood flow density. Early treatment of acute CSC is recommended to prevent progression and potential vision impairment.
Area of Science:
- Ophthalmology
- Retinal Imaging
- Vascular Biology
Background:
- Central serous chorioretinopathy (CSC) is a common fundus disease, particularly in middle-aged Asian men.
- Both acute and chronic CSC can impact retinal blood flow, potentially leading to vision damage.
Purpose of the Study:
- To compare blood flow density across different retinal capillary layers in acute and chronic CSC patients.
- To utilize optical coherence tomography angiography (OCTA) for detailed microvascular analysis.
Main Methods:
- Enrolled 12 patients with acute CSC, 8 with chronic CSC, and 17 normal controls.
- Performed 3 mm×3 mm and 6 mm×6 mm macular OCTA scans.
- Analyzed vessel density in superficial (SVC), intermediate (ICP), and deep capillary plexuses (DCP), and the inner retina.
Main Results:
- Chronic CSC eyes showed significantly lower blood flow density in the DCP and inner retina compared to acute CSC and normal eyes.
- No significant differences in SVC or ICP blood flow density were found among the groups.
- Acute CSC eyes showed no significant difference in blood flow density compared to normal eyes.
Conclusions:
- Reduced vessel density in the deep capillary plexus and inner retina in chronic CSC eyes may impair visual function.
- Prompt treatment of acute CSC is advised to prevent progression to chronic CSC and preserve vision.
